个人简介
朱建华,作为主持人承担了1项国家自然科学基金课题、1项广州市珠江科技新星项目、1项省自然科学基金课题、1项中医药局科研项目以及2项暨南大学创新与培育基金课题的研究;作为第二申请人承担了1项广州市科技重大专项、作为第三申请人承担了2项国家自然科学基金课题、作为子课题负责人承担了2项国家科技重大专项课题的研究工作。目前,已在«Process Biochemistry»、«Fitoterapia»、«ChineseChemicalLetters»、«中国药学杂志»、«中草药»、«中药材»等国内外期刊上发表文章25篇,包括SCI论文10篇;参编专著2部,参编实验指导书3部;申请发明专利4项,包括国际专利1项。参加学术团体任职情况:国家自然科学基金同行评议专家,广东核磁共振学会成员,«NaturalProductResearch»审稿专家。
科研成果
主要研究方向:天然药物活性成分的生物合成和生物转化
近三年主持及承担的项目:项目名称 | 起止时间 | 下达任务单位 | 经费(万元) | 课题组排名 |
新型诱导子青蒿酸对长春花培养物中生物碱合成的诱导与代谢调控机制研究 | 2012-01-01--2014-12-31 | 国家自然科学基金 | 22 | 1 |
基于银杏干细胞培养体系的海松二烯生物合成银杏内酯及其代谢调控研究 | 2014-01-01--2016-12-31 | 广州市珠江科技新星 | 30 | 1 |
新型诱导子青蒿酸对长春花生物碱诱导及调控机制研究 | 2011-10-10--2012-10-31 | 广东省自然科学基金基金 | 3 | 1 |
基于植物干细胞培养体系的喜树碱生物合成及其代谢调控研究 | 2012-01-01--2013-12-31 | 暨南大学培育与创新基金 | 10 | 1 |
新型诱导子青蒿酸对长春花细胞中生物碱合成的诱导与代谢调控机制研究 | 2011-01-01--2011-12-31 | 暨南大学培育与创新基金 | 2.5 | 1 |
展开表格近年发表论文情况:1.Novel biotransformation processes of dihydroartemisinic acid and artemisinic acid to their hydroxylated deri-vatives by two plant cell culture systems. Process Biochemistry, 2010, 45: 1652-1656.(SCI,第一作者)
2. Enhancementofvindolineandvinblastineproductioninsuspension-culturedcellsofCatharanthusroseus by artemisinicacidelicitation.WorldJMicrobiolBiotechnol.publishedonline,2013,6:DOI10.1007/s11274-013-1432-z.(通讯作者)
3.Two new compounds from transgenicPanax quinquefolium. Fitoterapia, 2010, 81: 339-342.(SCI, 第一作者)
4.A new ceramide from transgenic crown galls ofPanax quinquefolium. Chinese Chemical Letters, 2009, 20: 447-449.(SCI,第一作者)
5.Three sesquiterpene compounds biosynthesized from artemisinic acid using suspension-cultured cells ofAverrhoa carambola. Natural Product Research, 2012, 26(15): 1388-1394.(SCI,第二作者)
6. Biotransformation of paeonol and emodin by transgenic crown galls ofPanax quinquefolium.Applied Bioche-mistry and Biotechnology, 2010, 160: 1301-1308. (SCI,第三作者)
7.Biotransformation of eugenol by transgenic crown galls ofPanax quinquefolium and cell suspension cultures ofNicotiana tabacum. World Journal of Microbiology and Biotechnology, 2010, 26: 1201-1205.(SCI,第三作者)
8.Stereo and region-selective biosynthesis of two new dihydroartemisinic acid glycosides by suspension-cultured cells ofArtemisia annua. Pharmacognosy Magazine, accepted on 21/Feb/2013. (SCI,第一作者)
9.Biosynthesis pathways of ginkgolides. Pharmacognosy Reviews, accepted on 09/Jan/2013. (SCI,第二作者)
10. ANewAntiproliferativeandAntioxidantPeptideIsolatedfromArcasubcrenata.Marinedrugs,2013, 11:1800-1814.(SCI,第四作者)
11.Impact of artemisinic acid on the growth and catharanthine accumulation in Catharanthus roseus cell cultures. Journal of Medicinal Plants Research, 2012, 6(10): 2019-2028. (共同第一作者)
12.Jianhua Zhu, Wei Wen, Yanshan Hu, Yu Tang, Rongmin Yu: Hydroxyl Octadecenoic Acids Biosynthesized by Crown Galls of Panax quinquefolium Induced by Artermisinic Acid (in English). Journal of Chinese Medicinal Materials. 35(6): 869-872. (第一作者)