人物经历
1999年9月至2003年7月就读于吉林大学生命科学学院生物制药专业,2003年9月考入南开大学微生物学系攻读研究生,2008年7月获得理学博士学位后留校任教。
研究方向
微生物药物高通量筛选,基于结构基因或蛋白的药物分子设计。
主要贡献
1. Limei Ren, Xiaofang Cao, Peng Geng, Fang Bai*, Gang Bai. Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors. Carbohydrate Research, 2011, 346: 2688-2692.
2. Peng Meng, Yuanqiang Guo, Qi Zhang, Jie Hou, Fang Bai*, Peng Geng, Gang Bai. A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase. Carbohydrate Research, 2011, 346: 1898-1902.
3. Xiaohong Qin, Limei Ren, Xue Yang, Fang Bai, Lele Wang, Peng Geng, Gang Bai, Yuequan Shen. Structures of human pancreatic a-amylase in complex with acarviostatins: Implications for drug design against type II diabetes. Journal of Structural Biology, 2011, 174: 196-202.
4. Limei Ren, Xiaohong Qin, Xiaofang Cao, LeleWang, Fang Bai, Gang Bai, Yuequan Shen. Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein & Cell, 2011, 2(10): 827–836.
5. Fang Bai, Haijin Xu, Qi Zhang, Xizhen Qi, Rui Mou, Gang Bai, Mingqiang Qiao. Functional characterization of pfm in protein secretion and lung infection of Pseudomonas aeruginosa. Canadian Journal of Microbiology, 2011, 57: 829-837.
6. Rui Mou, Fang Bai, Qiaonan Duan, Xuehan Wang, Haijin Xu, Yanling Bai, Xiuming Zhang, Shouguang Jin, Mingqiang Qiao. Mutation of pfm affects the adherence of Pseudomonas aeruginosa to host cells and the quorum sensing system. FEMS Microbiology Letters, 2011, 324(2):173-80.
7. Peng Geng, Gang Bai, Xiansheng Meng, Fang Bai, Guoan Luo. Screening for metabolites of acarviostatin family aminooligosaccharides in rats using ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2009, 50: 917–923.
8. Fang Bai, Yingli Li, Haijing Xu, Huiming Xia, Tengfei Yin, Hongming Yao, Lu Zhang, Xiuming Zhang, Yanling Bai, Shouguang Jin and Mingqiang Qiao. Identification and functional characterization of pfm, a novel gene involved in swimming motility of Pseudomonas aeruginosa. Gene, 2007, 401: 19-27.
先后主持南开大学青年教师研究资助项目、天津市自然科学基金、国家自然科学基金,并参与国家高技术研究发展计划(863计划)等项目。